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Placebo-Controlled Trial of Positive Airway Pressure

Vital signs and spirometry were performed at the same time intervals as in the control group. Bedside spirometry and vital signs were recorded also 1 h after completion of 3 h of BPV treatment Viagra pills online. One hour after completion of the trial, patient data including spirometry results (mainly FEV1 and peak expiratory flow rate [PEFR]) and vital signs were presented to the attending physician. The attending physician would then make a decision regarding hospitalization and/or continuation of conventional treatment based on spirometric data and clinical grounds. Positive Airway Pressure

Criteria used by the attending physician were similar to the primary end point, ie, an increase of at least 50% in FEV1 as compared to baseline value on hospital admission or an increase in FEV1 to > 60% of the predicted value. The investigating team did not intervene in decision making regarding discharge or admission to the hospital or in the treatment plan. Neither the patient nor the attending physician knew the patient’s assigned group and thus were blinded to the results of the randomization. Since respiratory pressures had to be titrated individually to each patient, knowledge of the patient’s assigned group could not be concealed from the investigating team.

Statistical Analysis

The primary outcome variable was improvement in lung function test results during a short period stay in the emergency department, and the secondary end point was the need to hospitalize. Results are given as mean ± SD, and the group means were compared by t test. All tests and p values are two-tailed. A p value of < 0.05 was considered statistically significant. Categorical data were analyzed using the x2 test. Yates correction was used for a two-by-two table.

The study population for the secondary end point analysis—the rate of hospitalization—was defined as ah patients who were randomized and entered the study, either to the control group or to the BPV group. An intention-to-treat analysis was performed for this secondary variable using a two-tailed Fisher exact test. The SPSS statistical software package (SPSS; Chicago, IL) was used.

Results in viagra-online.com.au

During the study period, a total of 124 asthmatic patients were seen at the emergency department. Two patients had pneumonia, and 85 patients presented with an FEV1 > 60% of predicted; therefore, these patients were excluded. Thirty-seven patients (29.8%) fulfilled the severe asthma inclusion criteria, and 4 patients refused to participate in the study. Three patients, one of them in the control group, could not tolerate the nasal mask and did not complete the 3-h protocol; they were withdrawn from the study. Altogether, 30 patients entered the study, and all completed the study protocol without any side effects. Except for the two patients with pneumonia, none of the 85 patients who did not meet the inclusion criteria for entering the study, and none of the 3 patients who were withdrawn from the study were hospitalized.

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